В этой теме нет ответов

[Ruthen]

Global pharmacogenetics: genetic substructure of Eurasian populations and its effect on variants of drug-metabolizing enzymes
Makeeva O, Stepanov V, Puzyrev V, Goldstein DB, Grossman I.
Pharmacogenomics. 2008 Jul; 9(7): 847-68

Aims: To study the frequency distribution of cytochrome P450 (CYP) functional genetic variants in five Eurasian populations from the territory of Siberia in Russia.

Materials & Methods: Unrelated healthy Tuvinians, Buryats, Altaians, Yakuts and Russians (n = 87–88) were genotyped for CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP3A5*3 and CYP3A5*6. Standard pairwise genetic distances, locus-specific and global Fst statistics were calculated.

Results: CYP allele and genotype frequencies demonstrated significant variability. Overall, the degree of between-population variance displayed by CYP SNPs was lower than that recorded from neutral short tandem repeats and Alu-insertion polymorphism, indicating evolutionary conservation of CYP polymorphisms. CYP-based genetic distances were well correlated with the geographic distances across populations (r = 0.822, p = 0.008).

http://www.medgeneti...o...a et al.pdf